Another Pain Killer Bites the Dust

Below is an article written by Bernard Abrams, MD about the new FDA warning put out about the possible life threatening drug reaction that can be associated with taking Ultram or Ultracet for pain management. I have transcribed it verbatim sans some really technical information. The article can be found on pain.com

For my personal experiences with Ultram go to the “Healing Tips” page.

Ultram

FDA labeling change cites possible Tramatol may cause serotonin syndrome.

Tramadol, marketed under the brand names Ultram and Ultracet, is a weak mu-opioid agonist often used in pain management in lieu of stronger opioid. On September 9, 2009, the FDA added a warning on the possible association with serotonin syndrome, a potentially life threatening condition characterized by mental confusion, agitation, and hallucinations; autonomic problems such as tachycardia, labile blood pressure, and hyperthermia; neuromuscular manifestation such as hyperflexia, incoordination, and ataxia; and gastrointestinal symptoms such as diarrhea, nausea, and vomiting.

This syndrome may occur with Tramadol alone in usual therapeutic doses, but more commonly in combination with antidepressants.

Glossary of terms:

Serotonin Syndrome - a potentially life threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells.

mu-opioid – a specific opioid receptor cite targeted by the drug

ataxia - gross lack of coordination of muscle movements

hyperthermia -  elevated body temperature due to failed thermoregulation

hyperflexia - overreactive or overresponsive reflexes

I am grateful in yet another way that we have a SCENAR and can share this technology with others. If you have pain, call us at 828-337-6854 for an appointment.

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